Shares of Relmada Therapeutics Inc. RLMD, -78.23% fell 80.0% in premarket trading on Thursday after the biotech said its experimental treatment for major depressive disorder as a monotherapy did not meet the primary endpoint in a Phase 3 clinical trial. The company said it is still enrolling patients in two other late-stage studies assessing the therapy as an adjunctive treatment. Relmada’s stock is up 40.6% this year, while the broader S&P 500 SPX, +2.10% is down 24.7%.
Brent crude slips to 62.38 USD on Tuesday. Negotiations involving the US continue. Discover more in our analysis for 25 November 2025. Brent forecast: key
American Express: ⬆️ Buy – American Express reversed from support area – Likely to rise to resistance level 370.00 American Express recently reversed from support