Shares of Zymeworks Inc.          ZYME,         +9.00%        gained 8.4% in premarket trading on Wednesday after the company announced a licensing deal with Jazz Pharmaceuticals plc          JAZZ,         -1.95%        for its cancer drug, zanidatamab, which is currently being tested as a treatment for some HER2-expressing cancers. Jazz will pay  Zymeworks $50 million upfront. Including all regulatory and commercial milestone payments, the deal, which is expected to close before the end of the year, is worth up to a total $1.7 billion. Zymeworks’ stock is down 66.7% this year, while the S&P 500          SPX,         -0.36%        has declined 21.9%.